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How T-cell targets look in three dimensions may facilitate new cancer vaccines

How T-cell targets look in three dimensions may facilitate new cancer vaccines

T-cells, which hunt for traces of disease within other cells, work by identifying fragments of outsider proteins on a diseased cell’s surface and then go in for the literal kill.

With cancer, some of the mutated fragments of outsider proteins, called neoepitopes, can be recognized by T-cells and are ideal candidates for cancer vaccines. Unfortunately, those candidates are difficult to predict from genetic data alone.

 

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Francis Castellino Receives 2020 ISTH Esteemed Career Award

Francis Castellino Receives 2020 ISTH Esteemed Career Award

Author: Mary Prorok

 

Francis J. Castellino

Francis J. Castellino, Kleiderer-Pezold Professor of Biochemistry and Director of the W.M. Keck Center for Transgene Research, has been selected as a recipient of the 2020 International Society on Thrombosis and Haemostasis (ISTH) Esteemed Career Award. This prestigious award is given to those who “have made significant contributions to the understanding, treatment and diagnosis, research and education in the thrombosis and hemostasis field.” Five recipients are selected annually.

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Common cholesterol drugs could slow spread of breast cancer to brain

Common cholesterol drugs could slow spread of breast cancer to brain

A new study from the University of Notre Dame shows drugs used to treat high cholesterol could interfere with the way breast cancer cells adapt to the microenvironment in the brain, preventing the cancer from taking hold. Patients with breast cancer who experience this type of metastasis typically survive for only months after the diagnosis.

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Understand and Fight: Notre Dame researchers and the COVID-19 pandemic

Understand and Fight: Notre Dame researchers and the COVID-19 pandemic

The hero in Mary Shelley’s “The Last Man,” her second sweeping political science fiction after “Frankenstein,” is left alone in Rome, in a post-apocalyptic world. A global plague apparently took the lives of everyone else, yet he discerns a duty to forge ahead, no matter what.

Published in 1826, the novel mirrored Shelley’s life as she despaired at the loss of several of her loved ones. Her sister Fanny died by suicide. Her husband, the poet Percy Bysshe Shelley, drowned after a sailing accident. She lost another friend, the poet Lord Byron, to infection. Two of her toddlers died — one of malaria, and another from a fever. She kept a kind of plague journal, according to Eileen Hunt Botting

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Mary Galvin: It is more meaningful to ask what we can do to end intolerance

Mary Galvin: It is more meaningful to ask what we can do to end intolerance

Mary E. Galvin, William K. Warren Foundation Dean of the College of Science, addressed the issue of inequality with the students, faculty, and staff of the college:

Like many of you, I am deeply saddened by the recent killings of George Floyd, Breonna Taylor and Ahmaud Arbery and by this vivid reminder of the racism and inequality that persists throughout our country.…

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Dean Carlson: letter to graduate students on resolved issues

Author: Andy Fuller

Dear Graduate Students,

Let me start by thanking you for all that you are doing to continue your learning and research through these challenging circumstances.  And, thank you for reaching out to us as you have questions.  We are working through these, and a seemingly endless list of other issues that are unique for this time.  Below I provide an update on the issues that have been resolved.  Please keep asking and bringing to our attention any additional unique needs.  

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