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Researchers show how early RNA-based life may have repaired its genome, providing insight into the origins of life

Researchers show how early RNA-based life may have repaired its genome, providing insight into the origins of life

In a study published in Nature Communications, Saurja DasGupta, a biochemist at the University of Notre Dame, and colleagues present a key mechanism for sustaining RNA-based life: an engineered enzyme that selectively recognizes and repairs broken RNA.

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Study reveals how bacteria assemble their envelope

Study reveals how bacteria assemble their envelope

Red protein molecule interacting with a blue helical structure and a white polymer chain, showing a luminous binding site.
The protein PA2854 (shown in red) in Pseudomonas aeruginosa links the outer-membrane protein OprI (shown in blue) to the cell wall (depicted in white), a process that is necessary for the health of the bacterium. (Graphic provided by the Mobashery Lab)

Researchers at the University of Notre Dame and collaborators have discovered a key process for how the outer membrane of gram-negative bacteria attaches to the cell wall, advancing the understanding of how these bacteria frequently manifest resistance to antibiotics.

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First comprehensive look at breast cancer in Native American women reveals key genetic differences

First comprehensive look at breast cancer in Native American women reveals key genetic differences

Author: Brandi Wampler

Researchers from the University of Notre Dame have published the first known detailed study of breast cancer tissue from Native American women. The study, published in npj Precision Oncology, reveals important molecular differences that may impact the efficacy of therapies for female, Native American breast cancer patients.

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Douglas and Diana Berthiaume make groundbreaking gift to support strategic investment in biomedical research infrastructure

Douglas and Diana Berthiaume make groundbreaking gift to support strategic investment in biomedical research infrastructure

Author: Erin Blasko

Douglas and Diana Berthiaume have made a transformational gift to the University of Notre Dame to advance biomedical research through strategic investments in critical infrastructure. The gift, totaling $35 million, establishes the Center for Biomedical Discovery. It includes $5 million in seed funding for multidisciplinary research teams, promoting new collaborations among biomedical researchers in the Colleges of Science and Engineering.

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Department of Chemistry & Biochemistry Among 2026 Canvas Legends Award Winners

Department of Chemistry & Biochemistry Among 2026 Canvas Legends Award Winners

Author: Laura Cira

When Notre Dame students go to access their course materials online, it’s highly likely their instructor is sharing them through the Canvas learning management system. The Canvas Legends Awards, sponsored by the Office of Information Technology’s Teaching & Learning Technologies team, place the spotlight on faculty turning that seemingly routine task into an art.

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Notre Dame researchers to advance detection and community knowledge of opioids, including new variants

Notre Dame researchers to advance detection and community knowledge of opioids, including new variants

Author: Monica Sayler

Four teams of researchers across the College of Science and the College of Engineering have been selected to receive seed funding from the Notre Dame Sensor Initiative (NDSI) for research advancing affordable, fast, and accurate platforms for on-site…

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Notre Dame researchers uncover the molecular driving force behind hallmark of aggressive, metastatic cancers

Notre Dame researchers uncover the molecular driving force behind hallmark of aggressive, metastatic cancers

To invade healthy tissues and continue growing, aggressive cancers mimic and circumvent the body’s native piping system of veins and arteries. Through this process, known as vasculogenic mimicry (VM), tumor cells form fluid-conducting channels that transport blood, oxygen, and nutrients directly to…

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Steven Corcelli named William K. Warren Foundation Dean of the College of Science

Steven Corcelli named William K. Warren Foundation Dean of the College of Science

Author: Kate Garry

Steven A. Corcelli, professor of chemistry and biochemistry at the University of Notre Dame, has been appointed the William K. Warren Foundation Dean of the College of Science by University President Rev. Robert A. Dowd, C.S.C., effective April 1. Corcelli, who has served as interim science dean since July, was selected through a comprehensive national search launched after his predecessor, Santiago Schnell, was appointed as Dartmouth’s provost.

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Leading biomedical engineer John Fisher to direct Notre Dame’s Bioengineering & Life Sciences Initiative

Leading biomedical engineer John Fisher to direct Notre Dame’s Bioengineering & Life Sciences Initiative

Author: Kate Garry

Internationally recognized biomedical engineer John Fisher will join the University of Notre Dame as director of the campus-wide Bioengineering & Life Sciences Initiative (BELS) and Arthur J. Schmitt Professor in the Department of Aerospace and Mechanical Engineering. His appointment begins Aug. 1. Fisher is currently chair of the Fischell Department of Bioengineering at the University of Maryland, where he is Distinguished University Professor, MPower Professor, and Distinguished Scholar-Teacher. At Notre Dame, he will succeed Paul Bohn, who retired in December as inaugural director of BELS and Arthur J. Schmitt Professor of Chemistry and Biochemistry.

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Emerging scientists take center stage at Notre Dame’s COSE Research Horizons Symposium

Emerging scientists take center stage at Notre Dame’s COSE Research Horizons Symposium

Author: Subash Gamage

What does storm-driven coastal erosion in Ireland have in common with protein quantification, social behavior in prairie voles, and next-generation membrane technologies? On December 11, 2025, the answer was on full display at the annual Colleges of Science and Engineering (COSE) Research Horizons Symposium at the University of Notre Dame.

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Notre Dame's Rad Lab shepherds in next generation of radiation research with historic expertise

Notre Dame's Rad Lab shepherds in next generation of radiation research with historic expertise

When the Radiation Research Building was blessed by Father Theodore Hesburgh during its dedication on September 1, 1963, then-Chairman of the Atomic Energy Commission (AEC) Glenn Seaborg heralded the new laboratory as the nation’s foremost center for the production of scientists in the highly specialized…

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As an international research collaboration, the Biseach Initiative aims to improve cancer outcomes

As an international research collaboration, the Biseach Initiative aims to improve cancer outcomes

A transatlantic effort is transforming cancer research and care. The University of Notre Dame's Harper Cancer Research Institute is conducting collaborative, cutting-edge research with the University of Galway's Cancer Centre. The initiative is aptly titled Biseach — an Irish word meaning “to heal,…

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New computational process could help condense decades of disease biology research into days

New computational process could help condense decades of disease biology research into days

At 10 one-millionths of a meter wide, a single human cell is tiny. But something even smaller exerts an enormous influence on everything a cell does: proton concentration, or pH. On the microscopic level, pH-dependent structures regulate cell movement and division. Altered pH response can accelerate…

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Managing director brings interdisciplinary background to Bioengineering & Life Sciences Initiative

Managing director brings interdisciplinary background to Bioengineering & Life Sciences Initiative

Author: Tracy DeStazio

BELS, which is a joint initiative of Notre Dame’s College of Engineering and College of Science and a key priority in the University’s strategic framework, supports research that applies engineering principles to biological systems. The BELS Initiative works to create new technologies and approaches to the detection, prevention, and treatment of disease.

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Scientists Discover Key Protein Folding Step: A Race Between Folding and Misfolding

Scientists Discover Key Protein Folding Step: A Race Between Folding and Misfolding

Author: Samantha Keller

A breakthrough by researchers at the University of Notre Dame has uncovered a crucial step in the life of a protein that may determine whether it works properly or instead ends up misfolded and non-functional. Their findings reveal a surprising race at the heart of protein folding, and offer new hope…

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