Biophysics, literally the physics of life, enables scientists working at the intersection of physics, biology, chemistry, and applied mathematics and statistics, to collaborate with clinicians, mathematicians and engineers to develop a predictive understanding of biological processes, including cancer, development, infection and the immune system.  Novel tools and techniques now permit biophysicists to see and measure what was once invisible. Physics has long played a prominent role in biology – Watson, Crick and Franklin, discoverers of the structure of DNA, considered themselves biophysicists – but that role has increased dramatically in recent years as the development of new methods has transformed our understanding of biological systems, their complexity and their molecular details.

The University of Notre Dame has a rich history of molecular biophysics research across disciplines. The recent establishment of the Stavropoulos Center for Complex Quantum Matter will strengthen these efforts across campus, attracting elite research talent at all levels of career development.

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Researchers unlock details of the molecular machine critical for C. diff infections

Researchers unlock details of the molecular machine critical for C. diff infections

Researchers at the University of Notre Dame and collaborators have disclosed the core assembly of the germinosome, which is alarm system that awakens the dormant spores of Clostridioides difficile (C. diff), a health threat that causes about half a million infections and about 30,000 deaths a year.…

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Researchers show how early RNA-based life may have repaired its genome, providing insight into the origins of life

Researchers show how early RNA-based life may have repaired its genome, providing insight into the origins of life

In a study published in Nature Communications, Saurja DasGupta, a biochemist at the University of Notre Dame, and colleagues present a key mechanism for sustaining RNA-based life: an engineered enzyme that selectively recognizes and repairs broken RNA.

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