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Researchers unlock details of the molecular machine critical for C. diff infections

Researchers unlock details of the molecular machine critical for C. diff infections

Researchers at the University of Notre Dame and collaborators have disclosed the core assembly of the germinosome, which is alarm system that awakens the dormant spores of Clostridioides difficile (C. diff), a health threat that causes about half a million infections and about 30,000 deaths a year.…

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Researchers show how early RNA-based life may have repaired its genome, providing insight into the origins of life

Researchers show how early RNA-based life may have repaired its genome, providing insight into the origins of life

In a study published in Nature Communications, Saurja DasGupta, a biochemist at the University of Notre Dame, and colleagues present a key mechanism for sustaining RNA-based life: an engineered enzyme that selectively recognizes and repairs broken RNA.

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Study reveals how bacteria assemble their envelope

Study reveals how bacteria assemble their envelope

Red protein molecule interacting with a blue helical structure and a white polymer chain, showing a luminous binding site.
The protein PA2854 (shown in red) in Pseudomonas aeruginosa links the outer-membrane protein OprI (shown in blue) to the cell wall (depicted in white), a process that is necessary for the health of the bacterium. (Graphic provided by the Mobashery Lab)

Researchers at the University of Notre Dame and collaborators have discovered a key process for how the outer membrane of gram-negative bacteria attaches to the cell wall, advancing the understanding of how these bacteria frequently manifest resistance to antibiotics.

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