Events

Biophysics Seminar: David Stone (University of Illinois Chicago)

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Location: B01 McCourtney Hall

Title: "Mating yeast cells use an intrinsic polarity site to assemble a pheromone-gradient tracking machine"

David Stone, Professor of Biological Sciences, University of Illinois at Chicago

The mating of budding yeast depends on chemotropism, a fundamental cellular process. The two yeast mating types secrete peptide pheromones that binds to G protein-coupled receptors (GPCRs) on cells of the opposite type. Cells find and contact a partner by determining the direction of the pheromone source and polarizing their growth toward it. Actin-directed secretion to the chemotropic growth site (CS) generates a mating projection. When pheromone-stimulated cells are unable to sense a gradient, they form mating projections where they would have budded in the next cell cycle, at a position called the default polarity site (DS). Numerous models have been proposed to explain yeast gradient sensing, but none address how cells reliably switch from the intrinsically determined DS to the gradient-aligned CS, despite a weak spatial signal. We demonstrate that, in mating cells, the initially uniform receptor and G protein first polarize to the DS, then redistribute along the plasma membrane until they reach the CS. Our data indicate that signaling, polarity, and trafficking proteins localize to the DS during assembly of what we call the gradient tracking machine (GTM). Differential activation of the receptor triggers feedback mechanisms that bias exocytosis upgradient and endocytosis downgradient, thus enabling redistribution of the GTM toward the pheromone source. The GTM stabilizes when the receptor peak centers at the CS and the endocytic machinery surrounds it. A computational model simulates GTM tracking and stabilization, and correctly predicts that its assembly at a single site contributes to mating fidelity.…

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9th Annual Harper Cancer Research Day

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Location: The Morris Inn, Ballroom

Research Day is an excellent opportunity to learn about cancer research being conducted in our community. This event includes a poster session, lectures, and a Keynote Address.

RESEARCH DAY IS FREE AND OPEN TO THE PUBLIC.

REGISTRATION

Registration is required for all poster presenters and appreciated from everyone wishing to attend.  Register HERE

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