Magnetic Particle Imaging
Purposely designed to address research goals in immunology, cancer and therapeutic translational research
- Precision Cell Tracking: Enabling cell therapy development
- Disease Associated Inflammation: Early and sensitive diagnostic of the body’s response to disease
- Dynamic Vascular Function: Quantitative perfusion of the brain , kidneys, heat and lungs
- Theranostics: Drug delivery monitoring, hyperthermia, magnetic nanoparticle development
The success of cancer immunotherapy has driven the rapid growth of research in immuno-oncology. This has fueled the need to determine the bio-distribution of a variety of immune cells in solid tumors and systemically over time.
Magnetic Particle Imaging (MPI) is a novel preclinical imaging technique that can be used to non invasively track iron oxide tagged immune (and other) cells in vivo .
By combining accurate quantitation and specificity, MPI can provide information on macrophage and other immune cell biodistributions over time. MPI has also been used to track the biodistribution of stem, tumor and immune cells in vivo for weeks or even months. The same nanoparticles can also be used to generate heat for localized hyperthermia, as therapy or as an adjunct to radiation or immune therapies.
Results for both immune cell tracking and localized hyperthermia will be discussed.
Originally published at imaging.nd.edu.