Santiago Schnell

Santiago Schnell's research program departs from the premise that there is a continuum between health and disease; if we are capable of measuring this continuum, we will be in the position of detecting disease earlier and understanding it better to intervene more precisely. His research focuses on two broad areas: (i) the development of standard-methods to obtain high quality measurements in the biological and medical sciences, and (ii) the development of mathematical models of complex biomedical systems with the goal of identifying the key mechanisms underlying the behavior of the system as a whole.

The Schnell lab is presently working three new research projects: 

(i) Developing novel standard-based approaches to measure and report steady-state enzyme kinetics parameters with precision, rigor, and reproducibility,
(ii) Developing novel standard-based approaches to measure and report protein aggregation reaction mechanisms with precision, rigor, and reproducibility

(iii) Investigating the role of macromolecular crowding in cell physiology and biochemistry

Publications

1. "The quasi-steady-state approximations revisited: Timescales, small parameters, singularities, and normal forms in enzyme kinetics" Eilertsen, J.; Schnell, S. Math. Biosci. 2020, 325, 108339.
2. "Dynamic recruitment of single RNAs to processing bodies depends on RNA functionality" Pitchiaya, S.; Mourao, M. D.A.; Jalihal, A.; Xiao, L.; Jiang, X.; Chinnaiyan, A. M.; Schnell, S.; Walter, N. G. Mol. Cell. 2019, 74, 521-533.
3. "Do cellular condensates accelerate biochemical reactions? Lessons from microdroplet chemistry" Stroberg, W.; Schnell, S. Biophys. J. 115(1), 3-8. 
4. "Estimation of the lag time in a subsequent monomer addition model for fibril elongation" Shoffner, S. K.; Schnell, S. Phys. Chem. Chem. Phys. 2016, 18(31), 21259-21268.